posted 09-15-2002 07:09 PM            

Read about my evil twin

posted 09-15-2002 07:35 PM            

Then there's a well known DJ from across the pond but he didn't seem like an evil twin.

so i just had to go with the guy from The International Poetry Hall of Fame

posted 09-15-2002 07:45 PM            

Actually, my daughter looks exactly like me, so she is my twin...I'll call her "Mini-me."

posted 09-15-2002 09:23 PM            

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As from 1996, I have been responsible for establishing an in-house Sequence Analysis Service to support the EMBL research groups. Aidan Budd, Sophie Chabanis-Davidson, Chenna Ramu , Christine Gemünd, José Castresana, Rune Linding work with me. We maintain several web servers, including SRS (Sequence Retrieval Service), Gene2EST and a fast and sensitive Bioccelerator database search facility. We also run in-house courses on using EMBL's computational facilities. If you have some sequence analysis needs, come and talk to us.

My research interests involve the application of computers in molecular biology. In recent years, this has centred primarily on amino acid sequence analysis. I have worked on a number of domains and proteins where divergent sequence relationships have been informative, often in collaboration with structural groups who have solved several of the domain structures. Annalisa Pastore's group at Mill Hill have recently solved the structure of Frataxin, which is involved in the Inherited disease Friedreich's ataxia. With Rein Aasland, I have been interested in looking at chromatin-associated domains, such as the PHD finger and the SAND domain. Michael Sattler's group at EMBL have solved the DNA-binding SAND domain structure. With Jürg Spring, I have been looking at redundant genes in vertebrates, which seem to be differentially retained, depending on whether the phenotypes are dominant or recessive.

I am coordinator of an EU grant QLRI-CT2000-00127 which sets out our plans to develop a new protein motif database, the Eukaryotic Linear Motif resource, ELM (elm.eu.org). As well as EMBL, the other partners are Rein Aasland (Bergen), Bill Hunter (Dundee), Manuela Helmer-Citterich (Rome) and Giulio Superti-Furga (CellZome). There are many short functional motifs in modular proteins but it is difficult to provide good tools for their detection in query sequences due to a severe overprediction problem. The aim of the ELM project is to provide software filtering tools as well as the motif database, in order to reduce this problem. The first preliminary version of ELM should come online later in 2002.

Recently, I have been thinking about a nucleic acid agent for TSEs (spongiform encephalopathies). I have put forward a model, termed RuNAway Disease, for SINE retroposons as the transmissible agent with a mechanism to overproduce PrP, leading to amyloid plaque formation. Evidence for or against the model is scanty, but I hope to persuade TSE labs to do some testing. the RuNAway model has been posted on the GenomeBiology web set.

I have also been involved in some methods development projects. The multiple alignment programs Clustal W and Clustal X were developed together with Des Higgins (now at Cork) and Julie Thompson and colleagues (now in Strasbourg): we continue to maintain and develop Clustal W and X. Julie Thompson and I have also worked closely with Ewan Birney (now at the Sanger Centre) in the development of the WiseTools package of sequence comparison programs. WiseTools is a generalised sequence analysis system in which the user can compare combinations of proteins, profiles (from multiple alignments) and DNA translation frames. A frameshifting capability allows the user to match homologous proteins despite frameshifts caused by introns or sequencing errors.

More details may be found at our Official EMBL Team Page.

posted 09-16-2002 08:41 AM            

quote:

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Originally posted by Tobylifehater:
Hey Dyer- do you know of this guy?

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posted 09-17-2002 10:26 AM            

an artist(of the thomas kincaid caliber)

a cricket player(professional)

a video game creator for microsoft

a golfer (semi professional)

founder and head of the American Federation of Scientists

a character from the Andromeda strain

a comic book character

a historian

a child actor

and a porn writer/director

the list went on and on, and none of the bastards were me.

posted 09-17-2002 10:46 AM            

I'm a bible thumper: http://www.watchword.org/murphy/ww19c.html

I'm the Broadway triple threat of Writer, Lyricist, Composer: http://www.ibdb.com/person.asp?ID=7985

posted 09-17-2002 12:48 PM            

I think he's real proud of it because it's the only photo I could find on his site.

posted 09-17-2002 12:48 PM            

You know what!! I'm gonna have to track my evil twin down and do the Highlander style!
Damnit, there only one "Maria"!

Aarrggghhh!!

posted 09-17-2002 01:53 PM            

Criminal charges against Matthew Zacharias (Maha-mantra dasa, SDG) have been approved by the Crown Counsel. A warrant has been issued for his immediate arrest. Anyone knowing of his where abouts should please contact Constable S.McLeod of the Royal Canadian Mounted Police (RCMP) in Ashcroft, B.C., Canada, An arrest can be made worldwide. All information will be completely anonymous and confidential.

posted 09-17-2002 02:53 PM            

-Star Wars fanatic entirely too hung up on bad TV commercials.

-A 19th Century pottery manufacturer

-A champion of air pollution control in Connecticut

-and, a swimmer from 1985 at Gainesville, Florida - 3 titles for the 100 Breaststroke 54.6

posted 09-17-2002 03:53 PM            

quote:

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Originally posted by Slojo_Coma:
Star Wars fanatic entirely too hung up on bad TV commercials.

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posted 09-17-2002 04:39 PM            

quote:

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Originally posted by Chelsea40ozBondage:
So you are one of those trekkies, huh? Don't go posting any pictures of me without my permission!

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posted 09-18-2002 01:22 AM            

OAK RIDGE CEMETERY

Town of Springport Cemetery #208

Located on Rt 326 (Also called Crane Cemetery)

posted 09-18-2002 01:50 AM            

I AM AN ENTIRE BAND! And a shitty band to boot! http://www.renojones.com/

Just to show that i'm still a nice guy, I do take time away from gigging at supermarket grand openings to help folks get in shape. http://www.power-zone.com/thekeysprogram.htm

posted 09-18-2002 02:01 AM            

very strange thing to see your own
name in a cemetary.

posted 09-18-2002 07:14 AM            

Talk about close to home!

Now, Reno's band not topped, but I am trumpeter in The Azz Izz Band

And talk about your evil twin...get a load of this guy!

posted 09-18-2002 08:02 AM            

--Juan Diego 6, Juab 0
DRAPER -- Nicole Reather threw a shutout, striking out 12, and Natalie Blackwell went 3-for-4 with three RBIs as the Soaring Eagles won a Region 14 makeup game.

--The Access Facilitator for Children

--NIDETCH WOMEN'S CENTER HONORS 20 SCHOLARS

posted 09-18-2002 10:35 AM            

Apparently some hippie guy in Australia who is the member of the SOCIETY FOR BAREFOOT LIVING has written an on-line novel titled BAREFOOT TO THE STARS using my name for the main character. How cool is it to have your identity stolen by a hippie?

posted 09-18-2002 12:03 PM            

quote:

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Originally posted by UnstuckGus:
I think I'm more his evil twin than he is mine...
http://www.sunrecords.com/images/scans/6003.jpg

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posted 09-18-2002 06:40 PM            

quote:

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Originally posted by I got 70000000 crabs:
Wahhhhhhhhhhhh! I dont have an evil twin. The only one I have is my past self: Hennepin County arrest warrant for skateboarding on a public plaza and some article in The Rake . I suck.

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